Prednisone acetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

醋酸泼尼松是一种糖皮质激素受体激动剂，具有免疫调节特性和抗炎作用。

Prednisone acetate is a glucocorticoid receptor agonist with?immunomodulating properties and anti-inflammatory.

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Animal Model:C57BL/6 mice Dosage:5 mg/kgAdministration:Intragastric gavage (i.g.)Result:Significantly failed to gain weight.Decreased the population spike (%) after high-frequency stimulation.Reduced the crossing times compared with the control group.Resulted in the impairment of memory, and caused a trend of more serious impairment. Reduced the levels of Glu and gamma-aminobutyric acid (GABA) in the hippocampus. Reduced the expressions of N-methyl-D-aspartate receptors in the hippocampus.Animal Model:Experimental autoimmune uveitis Dosage:6 mg/kg Administration:gavage Result:Showed fewer manifestations in eyes from day 9 after immunization. Reduced the inflammation in EAU rats. Bound with the pocket of Notch signaling-related molecules with good affinity. Exhibited anti-inflammatory effects through inhibiting Notch signaling activation.

Prednisone 21-acetate

Endocrinology/Hormones

GR

Glucocorticoid Receptor

Infection

Henoch-Sch?nlein Purpura Nephritis

125-10-0

400.46

C23H28O6

>98% (HPLC)

DMSO:25 mg/mL (62.43 mM; Need ultrasonic)

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(-20℃)

With Ice Pack

≥ 2 years